bioRxiv Pharmacology and Toxicology

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The role of β-Nicotyrine in E-Cigarette abuse liability I: Drug Discrimination https://www.biorxiv.org/content/10.1101/2024.07.12.603310v1

The role of β-Nicotyrine in E-Cigarette abuse liability I: Drug Discrimination https://www.biorxiv.org/content/10.1101/2024.07.12.603310v1 www.biorxiv.org Background: {beta}-Nicotyrine ({beta}-Nic) is a unique minor alkaloid constituent in electronic nico

Interactive effects of temperature, cadmium, and hypoxia on rainbow trout (Oncorhynchus mykiss) liver mitochondrial bioenergetics https://www.biorxiv.org/content/10.1101/2024.07.15.603625v1

Interactive effects of temperature, cadmium, and hypoxia on rainbow trout (Oncorhynchus mykiss) liver mitochondrial bioenergetics https://www.biorxiv.org/content/10.1101/2024.07.15.603625v1 www.biorxiv.org Fish in their natural environments possess elaborate mechanisms that regulate physiological function

High-throughput drug screening for inhibition of influenza A virus infection based on human SIRT1 promoter and Genipin suppressing influenza A virus by activation of AMPK-SIRT1-PGC-1α signaling pathway https://www.biorxiv.org/content/10.1101/2024.07.10.602919v1 www.biorxiv.org The energy metabolism crisis is considered an important risk factor for severe influenza A virus (IA

Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice https://www.biorxiv.org/content/10.1101/2024.07.10.603000v1

Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice https://www.biorxiv.org/content/10.1101/2024.07.10.603000v1 www.biorxiv.org Accumulating evidence indicates that coronary microvascular dysfunction (CMD) caused by hypercholest

Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning https://www.biorxiv.org/content/10.1101/2024.07.05.602264v1

Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning https://www.biorxiv.org/content/10.1101/2024.07.05.602264v1 www.biorxiv.org Regional responses to inhaled toxicants are essential to understand the pathogenesis of lung disease

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments. https://www.biorxiv.org/content/10.1101/2024.07.04.602069v1

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments. https://www.biorxiv.org/content/10.1101/2024.07.04.602069v1 www.biorxiv.org Introduction: Tuberculosis (TB) poses a significant threat to global health, with millions of new in

Antimicrobial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase https://www.biorxiv.org/content/10.1101/2024.07.04.602096v1

Antimicrobial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase https://www.biorxiv.org/content/10.1101/2024.07.04.602096v1 www.biorxiv.org Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care

Evaluation of the efficacy of the protopine total alkaloids of Macleaya cordata (Willd.) R. Br. in controlling E. coli infection in broiler chickens https://www.biorxiv.org/content/10.1101/2024.07.03.601902v1 www.biorxiv.org Objective: This study was carried out to investigate the preliminary evaluation of the effectiveness

Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians https://www.biorxiv.org/content/10.1101/2024.07.03.601848v1 www.biorxiv.org Mental illnesses put a tremendous burden on afflicted individuals and society. Identification of nov

A murine experimental model of the unique pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus https://www.biorxiv.org/content/10.1101/2024.07.03.601850v1

A murine experimental model of the unique pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus https://www.biorxiv.org/content/10.1101/2024.07.03.601850v1 www.biorxiv.org Background The venom of Bothrops lanceolatus, a viperid species endemic to the Lesser Antillean Isla

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice https://www.biorxiv.org/content/10.1101/2024.07.02.601762v1

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice https://www.biorxiv.org/content/10.1101/2024.07.02.601762v1 www.biorxiv.org Immune checkpoint inhibitors (ICIs) that target programmed cell death 1 (PD-1) have revolutionized c

Alcohol induces p53-mediated apoptosis in neural crest by stimulating the AMPK-mediated suppression of TORC1, p70/S6K, and ribosomal biogenesis. https://www.biorxiv.org/content/10.1101/2024.07.02.601754v1 www.biorxiv.org Background. Prenatal alcohol exposure is a leading cause of permanent neurodevelopmental disability.

Leveraging machine learning to streamline the development of liposomal drug delivery systems https://www.biorxiv.org/content/10.1101/2024.07.01.600773v1

Leveraging machine learning to streamline the development of liposomal drug delivery systems https://www.biorxiv.org/content/10.1101/2024.07.01.600773v1 www.biorxiv.org Drug delivery systems efficiently and safely administer therapeutic agents to specific body sites. L

Exenatide administration time determines the effects on blood pressure dipping in db/db mice via modulation of food intake and sympathetic activity https://www.biorxiv.org/content/10.1101/2024.07.02.601700v1 www.biorxiv.org Type 2 diabetics have an increased prevalence of hypertension and nondipping blood pressure (BP), wh

The metabolic benefits of thermogenic stimulation are preserved in aging https://www.biorxiv.org/content/10.1101/2024.07.01.601572v1

The metabolic benefits of thermogenic stimulation are preserved in aging https://www.biorxiv.org/content/10.1101/2024.07.01.601572v1 www.biorxiv.org Adipose thermogenesis has been actively investigated as a therapeutic target for improving metabolic

Phosphodiesterase 3 inhibitors boost bone outgrowth https://www.biorxiv.org/content/10.1101/2024.07.01.601482v1

Phosphodiesterase 3 inhibitors boost bone outgrowth https://www.biorxiv.org/content/10.1101/2024.07.01.601482v1 www.biorxiv.org C-type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long b

In vitro genotoxic and mutagenic potentials of combustion particles from marine fuels with different sulfur contents https://www.biorxiv.org/content/10.1101/2024.06.27.601016v1

In vitro genotoxic and mutagenic potentials of combustion particles from marine fuels with different sulfur contents https://www.biorxiv.org/content/10.1101/2024.06.27.601016v1 www.biorxiv.org Ship emissions cause serious environmental impacts and adverse effects toward human health. Therefor

Differential Toxicity of Perfluorooctane Sulfonate (PFOS) in Wild-Type and Oatp1d1 Mutant Zebrafish Embryos https://www.biorxiv.org/content/10.1101/2024.06.28.601146v1

Differential Toxicity of Perfluorooctane Sulfonate (PFOS) in Wild-Type and Oatp1d1 Mutant Zebrafish Embryos https://www.biorxiv.org/content/10.1101/2024.06.28.601146v1 www.biorxiv.org This study presents a comprehensive analysis of the effects of perfluorooctane sulfonate (PFOS) expo

Interspecies interactions alter the antibiotic sensitivity of Pseudomonas aeruginosa https://www.biorxiv.org/content/10.1101/2024.06.27.601049v1

Interspecies interactions alter the antibiotic sensitivity of Pseudomonas aeruginosa https://www.biorxiv.org/content/10.1101/2024.06.27.601049v1 www.biorxiv.org Polymicrobial infections are infections that are caused by multiple pathogens, and are common in pat

Striking Long Term Beneficial Effects of Single Dose Psilocybin and Psychedelic Mushroom Extract in the SAPAP3 Rodent Model of OCD-Like Excessive Self-Grooming https://www.biorxiv.org/content/10.1101/2024.06.25.600634v1 www.biorxiv.org Obsessive compulsive disorder (OCD) is a highly prevalent disorder that causes serious disability. A

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice https://www.biorxiv.org/content/10.1101/2024.06.25.599576v1

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice https://www.biorxiv.org/content/10.1101/2024.06.25.599576v1 www.biorxiv.org Tobacco smoke remains a serious global issue, resulting in serious health complications, contributin

Anti-Toxoplasma gondii screening of eight species and bio-guided identification of metabolites of Elaeis guineensis leaves, a preliminary study https://www.biorxiv.org/content/10.1101/2024.06.24.600452v1 www.biorxiv.org The apicomplexan parasite Toxoplasma gondii causes toxoplasmosis, a ubiquitous and cosmopolitan para

Assessment of Antimicrobial Therapy in Eradicating Chlamydia muridarum in Research Mice: Immune Status and its Impact on Outcomes https://www.biorxiv.org/content/10.1101/2024.06.28.600682v1

Assessment of Antimicrobial Therapy in Eradicating Chlamydia muridarum in Research Mice: Immune Status and its Impact on Outcomes https://www.biorxiv.org/content/10.1101/2024.06.28.600682v1 www.biorxiv.org Chlamydia muridarum (Cm) is a moderately prevalent, gram-negative, intracellular bacterium that affe

Causal, Predictive Or Observational? Different Understandings Of Key Event Relationships For Adverse Outcome Pathways https://www.biorxiv.org/content/10.1101/2024.06.25.599864v1

Causal, Predictive Or Observational? Different Understandings Of Key Event Relationships For Adverse Outcome Pathways https://www.biorxiv.org/content/10.1101/2024.06.25.599864v1 www.biorxiv.org The difference between predictive and causal relationships has been a question in mechanistic toxico

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://www.biorxiv.org/content/10.1101/2024.06.24.600458v1

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://www.biorxiv.org/content/10.1101/2024.06.24.600458v1 www.biorxiv.org The nematode C. elegans has long served as a gold-standard model organism in aging research, particu

Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology https://www.biorxiv.org/content/10.1101/2024.06.23.600269v1

Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology https://www.biorxiv.org/content/10.1101/2024.06.23.600269v1 www.biorxiv.org Analysis of lifespan-extending compounds suggested the most effective geroprotectors target multiple

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner https://www.biorxiv.org/content/10.1101/2024.06.21.599604v1

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner https://www.biorxiv.org/content/10.1101/2024.06.21.599604v1 www.biorxiv.org Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those i

Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator https://www.biorxiv.org/content/10.1101/2024.06.22.600208v1

Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator https://www.biorxiv.org/content/10.1101/2024.06.22.600208v1 www.biorxiv.org NMDA receptor (NMDAR) channel blockers, which produce analgesic and anti-depressant effects, prefere

Scientific note on the potential beneficial effect of 1-octen-3-ol on the survival of Apis mellifera chronically exposed to low doses of fipronil. https://www.biorxiv.org/content/10.1101/2024.06.21.599996v1 www.biorxiv.org Fipronil, a non-competitive antagonist of gamma-aminobutyric acid receptors (GABA-Rs), inhibits the

Assessing mechanisms driving phenol isopropylated phosphate (IPP)- induced larval photomotor response deficits in zebrafish https://www.biorxiv.org/content/10.1101/2024.06.20.599969v1

Assessing mechanisms driving phenol isopropylated phosphate (IPP)- induced larval photomotor response deficits in zebrafish https://www.biorxiv.org/content/10.1101/2024.06.20.599969v1 www.biorxiv.org Phenol isopropylated phosphates (IPP) are an additive organophosphate flame retardant (OPFR) which h