Was it over when the Germans bombed Pearl Harbor?
In seriousness, now is the time to fight. We have an opportunity to do something great, and kick these bastards out, once and for all.
I really have lost my former tolerance for "we're doomed/fucked/it's all over/they've won" takes at this point, in that they're the most dangerous attitudes one could possibly have when confronted with a truly existential political threat (which we still DO have levers to address).