Trevor Graham

@trevorgraham.bsky.social

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Scientist studying cancer genomics and evolution, at the Institute of Cancer Research in London. Bad cyclist, slow runner, worse at tennis.

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Want to sequence the TCR repertoire in degraded or FFPE samples? Our new FUME-TCRseq method makes it easy (and cheap!). Led by the amazing Annie Baker in our lab at ICR London together with Benny Chain at UCL. aacrjournals.org/cancerres/ar...

FUME-TCRseq enables sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNAaacrjournals.org Abstract. Genomic analysis of the T-cell receptor (TCR) reveals the strength, breadth, and clonal dynamics of the adaptive immune response to pathogens or cancer. The diversity of the TCR repertoire, ...

"Gamechanging" this really is - regular endoscopy rolled out for people with Lynch syndrome in England. Brilliant progress @kevinjmonahan www.theguardian.com/society/2024...

‘Gamechanging’ cancer screening offered to people with Lynch syndrome in Englandwww.theguardian.com NHS bowel screening programme will offer specialist assessment every two years to people with condition

How do epigenome chromatin accessibility alterations contribute to the immunoediting of cancer genomes? @eszterlakatos.bsky.social explores in our new preprint www.biorxiv.org/content/10.1... in our 'EPICC' multi-omic colorectal cancer dataset @andreasottoriva.bsky.social

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancerwww.biorxiv.org bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Funded #PhD opportunity with Dr Barbara Bravi www.imperial.ac.uk/people/b.bra... and me on maths modelling of T-cell interactions in cancer using #TCRseq data. @ImperialMaths @ICR_London details here: github-pages.arc.ucl.ac.uk/Education/ph...

Lovely talk at UK Pathology Society meeting from our Dr Annie Baker @ICRLondon on her powerful FUME method for robust TCRseq of FFPE material. She's using it to dissect the dynamics of T-cell responses in longitudinally-followed metastatic colorectal cancer www.biorxiv.org/content/10.1...

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Trevor Graham

❣️I am looking for a motivated PhD candidate to join me in creating new methods for unraveling cancer evolution @chalmersuniv❣️ Exciting research (if I may say so), great work atmosphere and superb employment benefits❗️ Find out more and spread the word: www.chalmers.se/en/about-cha...

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Trevor Graham

Registration is now LIVE for the upcoming ISEEC conference in May 2024 at the Wellcome Genome Campus, UK (and virtual): coursesandconferences.wellcomeconnectingscience.org/event/cancer... ISEEC = International Society for Evolution, Ecology and Cancer. We have the funnest events! www.evocancer.com

Cancer Evolution: From Genome to Ecology — 20240508coursesandconferences.wellcomeconnectingscience.org Cancer Evolution: From Genome to Ecology

Big congratulations to Dr Qingli Guo for her successful PhD defence yesterday in Helsinki. Wonderful thesis pushing limits of what we can learn with #mutational signatures. Thanks to Ben Schuster-Böckler for examining & Ville Mustonen for supervising. Also check out those white bowties!!

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Trevor Graham

OK this is the mind-blowing image of the week for me: the total global biomass of mammals. Wild animals are a tiny proportion. From a paper by Ron Milo Lab at Weizmann Institute, via a great Oxford lecture by @marionkoopmans.bsky.social www.pnas.org/doi/10.1073/...

Our latest paper: measurement of cancer evolutionary dynamics at massive scale, using just a methylation array on bulk DNA. We find evolutionary dynamics strongly determine clinical outcomes in lymphoid malignancies. Fab collab with Inaki Martin & Marti Duran, & led by @calumgabbutt.bsky.social. A🧵

Does the evolutionary history of a cancer predict patient outcome? In our new pre-print, we introduce a powerful new method to measure a cancer’s past using bulk methylation data. In chronic lymphocytic leukaemia (CLL), these inferred histories are highly prognostic! (1/9) doi.org/10.1101/2023...

Lovely talk from @jasminefoo.bsky.social modelling EGFRi treatment in cancer. Explained ligand EGF produced in stroma, so treatment response is an interplay between stromal EGF level and kinetics of EGFRi administration. Jasmine have you considered resistance evolution, e.g. KRAS mutant subclones?

The hottest ticket in #mathonco ! Love the poster @sandyanderson.bsky.social

Just one week for this year's #Moffitt IMO #MathOnco workshop. Yes we are going to 11!

Found this article: www.nature.com/articles/s41... describing the development of next generation sequencing #NGS ("Illumina sequencing") well worth a read. The authors clearly explain the multidisciplinary technical hurdles that had to be jumped & the many different solutions considered on the way.

The chemistry of next-generation sequencing - Nature Biotechnologywww.nature.com A historical perspective on how next-generation sequencing chemistry was developed.

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Trevor Graham

I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"

An Owner's Guide to the Human Genomeweb.stanford.edu An Owner's Guide to the Human Genome

Too much oncogenic signalling is toxic for cancer cells, paper from Bill Sellers' group. www.nature.com/articles/s41... (& Kris Wood's wonderful commentary www.nature.com/articles/s41...). I'm excited by the potential that (counter-intuitive) oncogenic activation may have for new cancer therapies.

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