Cally: Thank you! Of four siblings, three of us have managed to stay novid (to the best of our knowledge) which makes me wonder if we've got the Covid immunity mutation. It might just be luck, though, so I'm still always masking indoors.

Via @nevadawolf.bsky.social: more evidence that histamine antagonists inhibit SARS-CoV-2 infection and replication and some work on determining the potential mechanism journals.asm.org/doi/10.1128/...

The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 | mBiojournals.asm.org In addition to human angiotensin-converting enzyme 2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can utilize alternative cofactors to facilitate viral entry. In this study, we discov...

Ok, which brand of antihistamine? Would any be good enough? Will add that to my list of preventative measures when next wave hits.

I have MCAS and take loratidine, cetirizine, and famotidine twice daily. For COVID prevention, loratidine or cetirizine + famotidine is probably good enough.

Twice daily or once daily?

if you're high risk, or work in a high risk environment, i'd go 2x per day. if not, 1x is probably sufficient. full disclosure - i take this style of combo meds 1x per day, am not high risk, and wfh. i've also only had covid 1x in the very 1st wave in jan 2020. never since.

^^ that, I take them twice daily but that's for MCAS, people at regular risk are probably okay with once a day unless there's someone in the house with it, in which case 2x/day

Do you think it matters if you take one of each 2x/day or two of one in the morning and two of the other in the evening? I'm thinking that in the run up to going to the dentist I'll take one of each twice a day and that way if I forget a dose I'll still have taken one of each.

I do 10mg cetirizine and 20mg of famotidine morning and evening (every 12 hours). Well, actually I also do 10mg of loratidine q12h as well, you get better results mixing them than just doubling the cetirizine, but I have MCAS and so I take a lot of fucking antihistamines, lol.

Multiple doctors have told me it's okay to take up to 80mg cetirizine + loratidine combined daily without any issue, and it's okay to go over that, but if you go over 80mg/day combined you should have quarterly kidney function bloodwork done.

So yeah, I recommend 10mg cetirizine OR loratidine + 20mg famotidine taken twice a day: the cetirizine/loratidine are H1 antagonists and the famotidine is a H2, and the research points to the combination being more helpful in prevention than just a H1 alone

Thank you! Of four siblings, three of us have managed to stay novid (to the best of our knowledge) which makes me wonder if we've got the Covid immunity mutation. It might just be luck, though, so I'm still always masking indoors.

Yeah, I'm the only one in my family still novid and I'm also the only one taking the fuckoff doses of antihistamines. I was also starting to wonder if I had the mutation and then I started seeing the research about antihistamines contributing to immunity!

I'm novid myself. Though I know at least once was due to sheer luck. Both of my roommates got it at one point, and I stayed with my girlfriend at the time for the two weeks until they both came back negative multiple times.

My wife has had it 3x and I still didn't get it! We were very diligent, but still.

There's a lot of luck involved, especially if you go out very frequently. I don't. And when I do, it's never a crowded place. Although, there is a lot of research into the anti-histamine like you said, and your anecdotal case is strong.

Yeah. I am not relaxing my precautions, but three times of no household transmission is a really strong argument for *something* I'm doing being right

I'm seriously hoping the what sometimes feels like handfuls of antihistamines (i think i have 8x h1 + 2x h2 daily as my baseline) is gonna help me with the fact i had a way way higher risk day yesterday than i'm comfortable with and tbh its what is keeping me from being in full on panic

i think my partner might've accidentally done this last time i caught the plague. he takes antihistamines daily for other reasons

i like to go to see bands fairly often & i always mask + oral rinse & nasal rinse after but ima apply this info to my going-out process going forward. ty.

I am strongly considering something like this for my upcoming scientific conference. The only thing I've done indoors without a mask is I am doing my archery class maskless. But there are (depending on week) 5-8 people total in a gym big enough for multiple basketball courts, for 1.5 hours.

This **exactly**

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