Protein Editing using a Concerted Transposition Reactiont.co bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Craig M. Crews
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation - Nature Communicationswww.nature.com Targeted protein degradation uses small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation, but only a few human E3 ligases are amenable to this strategy. Here,...
EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signalingwww.science.org Bifunctional PhosTACs combine the strength of a phosphatase and a kinase inhibitor to achieve dual inhibition of EGFR.
Molecular glues and induced proximity: An evolution of tools and discoverywww.cell.com Molecular glues are an underrepresented mode of drugging protein interaction, function,
and stability. Hand-in-hand, synthetic chemistry and biology are rapidly diversifying
the biochemical space of i...
An antibiotic built for better bindingcen.acs.org Cresomycin’s conformationally restricted structure makes a tight fit to bacterial ribosomes and pushes away methyl groups that can confer resistance
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