Oh my god, this is fucking huge. It was huge when we developed a daily PrEP pill that could prevent you from catching HIV; this is a successful phase III trial of a PrEP shot that will only need to be given *twice a year*. Still needs a confirmatory Phase III, but holy fuck.
0 seroconversions, N=2134, among sexually actively cisgender women in Uganda. Controls were other forms of PrEP (since placebo would be unethical): daily emtricitabine/tenofovir as Descovy had 39/2136, 2.02 per 100 person-years; as Truvada had 16/1068, 1.69 per 100.
Gilead's press release is www.gilead.com/news-and-pre... and the trial readout among cis MSM, and trans men, trans women, and nonbinary people who have sex with men in Argentina, Brazil, Mexico, Peru, South Africa, Thailand, and the US is expected late 2024/early 2025.
