Lol, tried everything to get my ublock to work with youtube. Luckily I saw the writing on the wall about a week ago when I started getting popups and tomorrow I'll have everything I need to set up a pi hole
Based on my (admittedly limited) understanding of how u-block and pi hole work, I don't see why one would succeed at blocking youtube ads and the other wouldn't. ublock isn't blocking an element of the page for those, it's blocking the source of the traffic.