Oh my god, this is fucking huge. It was huge when we developed a daily PrEP pill that could prevent you from catching HIV; this is a successful phase III trial of a PrEP shot that will only need to be given *twice a year*. Still needs a confirmatory Phase III, but holy fuck.
0 seroconversions, N=2134, among sexually actively cisgender women in Uganda. Controls were other forms of PrEP (since placebo would be unethical): daily emtricitabine/tenofovir as Descovy had 39/2136, 2.02 per 100 person-years; as Truvada had 16/1068, 1.69 per 100.
I KNOW. They were comparing against existing daily PrEP because placebo would be unethical and it outperformed CONSIDERABLY. 0.0/100. n=2134. Just, my god.
